ea0065oc6.4 | Reproductive Endocrinology and Biology | SFEBES2019
Lee Ji Young
, Kim Yeon Joo
, Ataliotis Paris
, Bennett Dorothy
, Brown Nigel
, Kim Soo Hyun
The primary cilium, a non-motile microtubule-based organelle protruding from most vertebrate cells, serves as a specialized compartment for signal transduction. Any disruption of ciliogenesis leads to ciliopathy-spectrum disorder with multiple signalling failure in development and homeostasis. Several ciliopathies including Bardet–Biedl syndrome associate with infertility and hormone imbalances, but the role of primary cilia in reproductive disorders is not clear. Congeni...